MPH-198
An efficient cardiac myosin inhibitor
CAT № MPH-198
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Email: info@motorpharma.com
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Price:
539 EUR/1 mg
2156 EUR/5 mg
| Name of chemical: | MPH-198 |
| Other names: | Cardistatin |
| Chemical name | (9S)-9-hydroxy-5-methyl-12-phenyl-4-thia-2,12-diazatricyclo[7.3.0.03,7]dodeca-1,3(7),5-trien-8-one |
| Cat. No: | MPH-198 |
| M.w: | 298.357 (C16H14N2O2S1) |
| Absorbance spectrum: | maximal absorbance at 445 nm in buffer (pH 7.3, 1% DMSO) |
| Maximal absorbance: | 432 nm in 100% DMSO |
| Chemical purity: | >95% |
| Ratio of (-) enantiomer: | >90% |
| Storage conditions: | In powder form or dissolved in DMSO in aliquots at -20 C to limit freezing-thawing cycles |
| Disclaimer: |
Motorpharma Ltd. holds the rights to distribute MPH-198 patented by Eötvös Loránd University and Printnet Ltd.
MPH-198 cannot be redistributed. |
FOR RESEARCH USE ONLY
| Solubility: | The equilibrium concentration of MPH-198 is 56 µM in water based buffers containing 1% DMSO. |
| Usage: | Use maximum 20 uM concentration to avoid aspecific effects. |
| Photostability: | Based on tests with HeLa cells unlike B, pNB is not phototoxic when irradiated with >440 nm wavelenght light. However, upon |
| Cytotoxicity: | After 1-2-5 days of incubation with 20 – 50 µM MPH-198, no cytotoxicity was observed in human dermal fibroblast cells. |
Myosin inhibition
|
Myosin type |
Inhibitory properties |
|
skeletal muscle myosin S1 (rabbit) |
100% inhibition |
|
Dictyostelium discoideum myosin II motor domain |
100% inhibition |
|
NM2A (human, heterologous expression) |
100% inhibition |
|
NM2B (human, heterologous expression) |
100 % inhibition |
|
NM2C (human, heterologous expression) |
100 % inhibition |
|
cardiac myofibrillum (porcine left ventricle) |
100 % inhibition |
|
smooth muscle S1 (chicken gizzard) |
100 % inhibition |
